Science Science

Biomarker-Driven Development

The development path of each program is enabled by biomarkers to monitor early effects of the drug and select the right patients and the right dose in clinical development.

Biomarker-Driven Development
Patient Engagement Biomarker

Target Engagement

In the design of our Phase 1 trials, we integrate our target engagement biomarker data with pharmacokinetic analysis from both plasma and CSF to determine the relationship between dose, time, drug exposure and drug response. We develop integrated exposure response models that enable quantitative dose selection for future patient studies.

Pathway Engagement Biomarker

Pathway Engagement

In building deep expertise in the biologic understanding of degenogenes, we can identify and use pathway biomarkers to monitor effects on target biology that may be relevant to human disease outcomes. Demonstration of pathway engagement further de-risks our targets by establishing an effect on the relevant biology.

Target Engagement Biomarker

Patient Phenotyping

Patient phenotyping is the intersection of Pathway Biology and Disease Pathology. In building deep expertise in both disease biology and the pathway biology of degenogenes, we enable a patient selection strategy that can better target and select the best patient population for our clinical trials and product candidates.

Product Candidate Biomarkers

As part of our strategy, we are developing proprietary reagents and assays to enable biomarkers for each of our core programs. These biomarkers, which are relevant for both animal models and human trials, are critical for patient selection, predicting and measuring target engagement, supporting dose selection and enabling decisions on progression of product candidates to the next phase of development.

  • Preclinical
  • Clinical Data
Target Target Engagement Biomarkers Pathway Engagement Biomarkers Patient Phenotyping Biomarkers
LRRK2 LRRK2pS935, Rab10pT73 Rab10pT73, BMP LRRK2 mutation
RIPK1 RIPK1pS166 Cytokines Nf-L, genetic data, Amyloid/Tau biomarkers of disease
ETV:IDS CNS GAGs BMP, lysosomal lipids IDS mutation, lysosomal lipids
ATV:aSyn Bound/free Synuclein   DAT imaging
ATV:TREM2 Bound/free sTREM2   Amyloid/Tau biomarkers of disease
ATV:Tau Abeta, pTau   Amyloid/Tau biomarkers of disease
  • Preclinical
  • Clinical Data
Target Target Engagement Biomarkers
LRRK2 LRRK2pS935, Rab10pT73
RIPK1 RIPK1pS166
ETV:IDS CNS GAGs
ATV:aSyn Bound/free Synuclein
ATV:TREM2 Bound/free sTREM2
ATV:Tau Abeta, pTau
  • Preclinical
  • Clinical Data
Target pathway engagement biomarkers
LRRK2 Rab10pT73, BMP
RIPK1 Cytokines
ETV:IDS BMP, lysosomal lipids
ATV:aSyn  
ATV:TREM2  
ATV:Tau  
  • Preclinical
  • Clinical Data
Target Patient Phenotyping biomarkers
LRRK2 LRRK2 mutation
RIPK1 Nf-L, genetic data, Amyloid/Tau biomarkers of disease
ETV:IDS IDS mutation, lysosomal lipids
ATV:aSyn DAT imaging
ATV:TREM2 Amyloid/Tau biomarkers of disease
ATV:Tau Amyloid/Tau biomarkers of disease