A Driven and Passionate Team
We are a team dedicated to defeating degeneration. We are passionate about solving problems with rigorous science and translational medicine. We have joined together to discover and develop therapies that will change the lives of patients suffering from neurodegenerative disease.
Senior Leadership
Ryan Watts
Chief Executive Officer
Ryan Watts
Chief Executive Officer
Ryan Watts is the Chief Executive Officer of Denali Therapeutics. He is a co-founder, President and a member of the Board of Directors.
Under Ryan's leadership, Denali has advanced multiple therapeutic candidates into clinical testing for Parkinson’s disease, Alzheimer’s disease, and ALS. Denali has invented a proprietary blood-brain barrier platform for delivery of therapeutic proteins to the brain. Ryan has also led efforts to raise significant capital to advance Denali’s therapeutic pipeline and has been instrumental in forging partnerships to accelerate the discovery and development of medicines for neurodegeneration.
Ryan previously served as Director of the Department of Neuroscience at Genentech. During his tenure there, he led the company’s re-entry into neuroscience. The Watts laboratory focused on drug discovery for cancer and Alzheimer’s disease, with an emphasis on understanding mechanisms of neurodegeneration guided by human genetics. His lab also studied various aspects of blood-brain barrier biology and delivery.
Ryan obtained his Ph.D. from Stanford University’s Department of Biological Sciences and his B.S. in Biology from the University of Utah.
Alex Schuth
Chief Operating Officer
Alex Schuth
Chief Operating Officer
Alex Schuth is Chief Operating Officer of Denali Therapeutics. He is a co-founder of the company and responsible for portfolio management, corporate development, and the legal group.
Since 2015, Alex and his team have helped build and advance a broad portfolio of therapeutic drug candidates from discovery stage to clinical development and established over 30 collaborations with partners in academia and industry to accelerate the discovery and development of medicines for neurodegenerative diseases.
Alex previously held various operational and leadership positions during a 10-year tenure at Genentech, including Head of Neuroscience Partnering, and contributed to the growth and success of Genentech’s pipeline across several therapeutic areas. Before joining Genentech, Alex worked in Merrill Lynch’s investment banking group in London, where his responsibilities included executing equity capital market transactions.
Alex holds an M.D. degree from the Charite Medical School at the Humboldt University in Berlin, Germany, and an M.B.A. from the Wharton School of the University of Pennsylvania.
Carole Ho
Chief Medical Officer
Carole Ho
Chief Medical Officer
Carole Ho is our Chief Medical Officer and Head of Development. At Denali, Carole has built an integrated Development organization that is responsible for advancing therapeutic candidates from pre-IND enabling studies through Phase 1 to Phase 3 clinical trials. Under Carole’s leadership, her team has delivered on Denali’s biomarker driven development strategy to enable early target and pathway engagement in the clinic for therapeutics in development for Parkinson’s disease, Alzheimer's disease, and ALS.
Carole previously served as Vice President of Genentech Early Clinical Development and was responsible for delivery of pivotal trial-ready drug candidates in Neurology, Ophthalmology, Immunology, and Infectious Disease. During her 8-year tenure at Genentech, Carole held roles with leadership responsibility across multiple early- and late-stage clinical programs including Rituxan® for Wegener’s granulomatosis and microscopic polyangiitis, ocrelizumab for Multiple Sclerosis, lampalizumab for dry AMD, and crenezumab for Alzheimer’s Disease. At Genentech, in collaboration with Banner Health, Carole's team led the initiation of the world's first prevention trial in Alzheimer's disease in participants at risk for dementia due to a genetic mutation.
Carole completed her residency in Neurology at Harvard Medical School at the Massachusetts General Hospital / Brigham and Women’s Hospital, where she also served as Chief Resident. She obtained her M.D. from Cornell University and S.B. in Biochemical Sciences from Harvard College. Prior to her Industry career, Carole was on Faculty in the Department of Neurology at Stanford University. Carole currently serves on the Board of Directors of Beam Therapeutics.
Steve Krognes
Chief Financial Officer
Steve Krognes
Chief Financial Officer
Steve Krognes is our Chief Financial Officer. He is responsible for finance, investor relations, procurement, corporate communications, IT and facilities.
Steve previously worked at Genentech and Roche for twelve years. At Genentech, he served as CFO and as a member of the Executive Committee for six years, where he was responsible for finance, site services and IT. Steve also represented Genentech on the Board and Executive Committee of the California Life Science Association and served as Chairman of the Genentech Access to Care Foundation.
At Roche in Switzerland, Steve led the global Mergers & Acquisition team for more than five years. Under Steve’s leadership, the M&A team executed more than 30 transactions worldwide, including the acquisitions of Ventana Medical Systems and Genentech. Steve worked as an investment banker at Goldman Sachs in London, a management consultant at McKinsey in London, and as a venture capitalist in Stockholm.
Steve holds an M.B.A. from Harvard Business School, a B.S. in economics from the Wharton School of the University of Pennsylvania and is a Second Lieutenant in the Royal Norwegian Air Force.
Dana Andersen
Chief Technical and Manufacturing Officer
Dana Andersen
Chief Technical and Manufacturing Officer
Dana Andersen is our Chief Technical and Manufacturing Officer and is responsible for overseeing the development of manufacturing processes, production, quality control & assurance and clinical supply to support the Denali therapeutic portfolio.
Previously, he worked at Genentech for nearly 23 years, most recently as Vice President and Global Head of Technical Development Project & Portfolio Management for the Roche large and small molecule development portfolio. Earlier he held several leadership roles spanning biologics manufacturing process development eventually becoming Vice President of Pharmaceutical Development.
Dana is a fellow of the American Institute for Medical and Biological Engineering and received a B.S. from the University of Colorado at Boulder, and a M.S. and Ph.D. from Stanford University, all in chemical engineering with a focus on biological systems.
Cindy Dunkle
Chief People Officer
Cindy Dunkle
Chief People Officer
Cindy Dunkle serves as Chief People Officer at Denali. In this position, she oversees all aspects of Human Resources and Environmental Health and Safety.
Cindy has been instrumental in the successful growth of the company, positioning science and leadership as a focus in attracting top talent. She drives HR strategy and value creation, fosters a culture of learning and innovation to enable each individual achieve their unique potential. Cindy has 25 years of experience with an emphasis in compensation, organizational development and talent acquisition.
Prior to Denali, Cindy held roles of increasing responsibility across corporate staffing and development functions at Avalanche Biotechnologies and Genentech. Cindy obtained a B.S. from Metropolitan State University.
Joe Lewcock
Chief Scientific Officer
Joe Lewcock
Chief Scientific Officer
Joe serves as CSO and Head of Discovery at Denali. In this role, he coordinates the discovery stage portfolio and activities ranging from new target discovery and validation to the identification of biomarkers to enable clinical trials. His group specializes in development of novel therapeutic strategies to address key aspects neurodegeneration biology including Lysosomal Function, Glial Biology, Axon/Synapse maintenance. As delivery to the brain represents a major challenge, Joe’s discovery team continues work on the Denali Transport Vehicle (TV) platform to shuttle candidate therapeutics across the Blood-Brain Barrier.
Prior to joining Denali in early 2016, Joe spent 9 years at Genentech, where he helped to build the neuroscience research team and portfolio. In his role as Director of the Department of Neuroscience, he was responsible for generating the disease area strategy and management of the neuroscience portfolio, which included both large and small molecule programs. During his time at Genentech, Joe also served as a project team leader where he led a small molecule program for neurodegenerative disease from target discovery to IND filing and led a discovery lab focused on identification of new therapeutic drug targets for Amyotrophic Lateral Sclerosis (ALS) and Alzheimer’s Disease. He received his BS from University of California, San Diego, a Ph.D. from Johns Hopkins University School of Medicine, and did a Postdoctoral fellowship at the Salk Institute.
Chris Walsh
Associate General Counsel
Chris Walsh
Associate General Counsel
Chris Walsh serves as Senior Vice President, Associate General Counsel. In this position, he built an integrated legal team focusing on accelerating Denali invention and protecting its value, maintaining a safe and inclusive work environment, and keeping Denali compliant as a global company.
Prior to joining Denali, Chris practiced intellectual property law in Genentech's Legal Department as Assistant General Counsel, Practice Group Leader, and he was in private practice as an associate attorney at the law firm Sterne, Kessler, Goldstein & Fox in Washington, D.C. Chris received a J.D. from the George Washington University Law School, completed postdoctoral training at Northwestern University and received a Ph.D. in chemistry from the Illinois Institute of Technology.
Dolo Diaz
Vice President, Development Sciences
Dolo Diaz
Vice President, Development Sciences
Dolo Diaz serves as the Head of Development Sciences at Denali. In this role she supports the DMPK, Clinical Pharmacology, Toxicology, Pathology and Nonclinical Operations teams in the advancement of Denali’s portfolio of small molecules and biotherapeutics.
Dolo was previously the Senior Director of Safety Assessment at Denali, in this role she built and led a group with expertise in toxicology, pathology, and non-clinical operations. Prior to that Dolo was the Head of Discovery Toxicology at Genentech, where for nine years she led compound optimization and safety strategies for the small molecule discovery portfolio across therapeutic areas. Dolo started her industry career at Eurofins, where she established and headed the In-vitro Toxicology group.
Dolo received her Ph.D. in Toxicology from the University of Washington, followed by post-doctoral work at the Fred Hutchinson Cancer Research Center in Seattle. She has a BS in Pharmacy from the University of Santiago de Compostela (Spain). Dolo has authored/co-authored more than 30 peer-reviewed publications and she is a Diplomate of the American Board of Toxicology.
Peter Chin
Vice President, Late Clinical
Peter Chin
Vice President, Late Clinical
Peter leads the Late Clinical function at Denali. In this role, he coordinates late stage clinical science and medical affairs activities as the portfolio advances through the lifecycle. His group facilitates the design and oversight of late stage clinical trials to support regulatory approval, augments the medical community’s understanding of neurological disease mechanisms, and characterizes the evidence base to support appropriate use of new therapeutics upon approval.
Peter most recently served as Group Medical Director for Neuroscience in U.S. Medical Affairs at Genentech and previously held leadership roles in neuroscience development at Genentech/Roche and Novartis, contributing to the global development and clinical application of therapies approved for relapsing and progressive forms of multiple sclerosis, including fingolimod, siponimod and ocrelizumab. For over a decade he has also engaged in advancing clinical research platforms through initiatives sponsored by NIH-NINDS, C-PATH, patient advocacy groups, and various academic-industry consortia.
Peter completed his B.A. in Molecular and Cell Biology at the University of California at Berkeley, M.D. at Dartmouth, neurology residency at the University of Washington, and fellowship as a Robert Wood Johnson Foundation Clinical Scholar at UCLA, where he also obtained an M.S. in Health Services through the School of Public Health.
Matt Troyer
Vice President, Early Clinical
Matt Troyer
Vice President, Early Clinical
Matt Troyer leads the Early Clinical function and is responsible for overseeing a team of physician-scientists who execute Denali’s early clinical programs. The Early Clinical group partners with pre-clinical teams, including Translational and Development Sciences, to design and conduct first-in-human, biomarker, experimental medicine and other early studies in healthy subjects and patients. Matt and the Early Clinical team execute the first clinical investigations that drive Denali’s biomarker-driven development strategy.
Matt is a neurologist with subspecialty training in Parkinson’s disease and Movement Disorders and 14 years of early clinical leadership. Matt previously led early development programs at Medivation and at Merck & Co., Inc. where he was Executive Director and Neuroscience Therapeutic Area lead for Early Clinical Development, with responsibility for pre-clinical to proof-of-concept programs in Alzheimer’s disease, Parkinson’s disease, sleep disorders, pain, migraine, schizophrenia and other CNS indications.
Matt completed neurology residency training at Harvard Medical School in the Longwood Area Program and completed a fellowship in Parkinson’s disease and Movement disorders at the Institute of Neurology, Queen Square, London. Following his clinical fellowship, Matt did a postdoctoral research fellowship in the laboratory of Robert Edwards at UCSF, focusing on basic mechanisms of presynaptic function and Parkinson’s disease. Matt subsequently joined the Neurology faculty at UCSF with both clinical and research responsibilities. Matt received his M.D. from Stanford University and a B.A. in biology from Illinois Wesleyan University.
Cynthia Wong
Vice President, Portfolio and Program Management
Cynthia Wong
Vice President, Portfolio and Program Management
Cynthia leads Portfolio Planning and Program Management at Denali and is responsible for Denali’s growing portfolio of 10+ programs in various stages of research and clinical development. Cynthia is the Program Director of Denali’s LRRK2 program. In addition, she is involved in developing and evolving Denali’s project team system and decision making processes to support a project-centric organization, whereby project teams are enabled to make high quality decisions with speed.
Prior to Denali, Cynthia was an Associate Director at Genentech’s Research and Early Development Portfolio Planning and Operations group, culminating a career of 12 years at Genentech. Cynthia managed programs from pre-IND through approval in the inflammation, ophthalmology, infectious disease, and oncology disease areas, including products on the market such as Ocrevus (ocrelizumab), Tecentriz (atezolizumab), and Lucentis (ranibizumab).
Cynthia has a B.A. from the University of California at Berkeley in Mass Communications and East Asian Studies.
Erica Kratz
Vice President, Regulatory
Erica Kratz
Vice President, Regulatory
Erica leads Regulatory Affairs and Clinical Quality Assurance at Denali. Erica’s team is responsible for leveraging Denali data to drive regulatory strategies for our novel therapies and ensuring Denali’s commitment to the highest Quality standards.
Prior to joining Denali, Erica held positions of increasing responsibility in Regulatory Affairs during 10 years at Genentech. Erica led the global regulatory strategy and execution for multiple small molecule and biologic oncology drug candidate programs ranging from IND to postmarketing, including leading the US and Canada marketing application filings for approval of Herceptin for gastric cancer and leading global Health Authority interactions in breast cancer and mesothelioma.
Erica earned her BS at the University of Arizona, and her Ph.D. at the University of California, Berkeley, in Molecular and Cell Biology.
Tyler Nielsen
Vice President, Corporate Finance
Tyler Nielsen
Vice President, Corporate Finance
Tyler Nielsen leads Corporate Finance at Denali and is responsible for investor relations, accounting, procurement and treasury.
Before joining Denali, Tyler was the Head of Corporate Finance at Sangamo Therapeutics where he was responsible for leading all financing activities as well as accounting, FP&A, facilities, procurement and IT functions. Tyler is a CPA (inactive) and was as an auditor at Ernst & Young in the firm’s Biotech and Technology practices.
Tyler graduated from Brigham Young University with a B.S. in accounting.
Anantha Sudhakar
Vice President, CMC Small Molecule
Anantha Sudhakar
Vice President, CMC Small Molecule
Anantha Sudhakar leads Small Molecule CMC at Denali and is responsible for process R&D, formulation and analytical development for small molecules in development as well as manufacturing of drug substances and drug products for clinical trials. Prior to this role, he was Senior Director, CMC.
Anantha has over 15 years of experience in process chemistry from Schering Plough (now part of Merck) in leading process chemistry and CMC teams and led the development of commercial processes for several small molecules in early and late stage development. He then moved on to lead CMC functions at several biotech companies in the bay area including Celera Genomics, Sunesis Pharmaceuticals, Achaogen and Virobay.
Anantha Sudhakar obtained his Ph.D. in Organic Chemistry from Columbia University and an MBA in Finance and Management from New York University. He was also a post-doctoral fellow at both University of Wisconsin at Madison and Stanford University.
Tony Estrada
Vice President, Small Molecule Discovery
Tony Estrada
Vice President, Small Molecule Discovery
Tony Estrada serves as the Head of Small Molecule Discovery at Denali.
In this role, he supports the Discovery Chemistry and Modeling and Informatics teams as well as coordinating activities for the small molecule discovery portfolio ranging from new target hit generation to the identification of IND-enabling drug candidates.
Prior to joining Denali in mid 2015, Tony spent seven years at Genentech as a Senior Scientist and Project Team Leader. During his industrial career, Tony has contributed to the invention and advancement of more than eight small molecules that have progressed into clinical studies spanning neurodegenerative diseases, oncology and inflammatory diseases. Tony has co-authored approximately 45 patent applications and 30 scientific articles. Tony obtained his Ph.D. in organic chemistry from the University of California, San Diego.
Darren Hart
Vice President, Development Operations
Darren Hart
Vice President, Development Operations
Darren Hart serves as the Head of Development Operations at Denali. In this role he oversees Clinical Outsourcing & Business Operations, Clinical Operations and Data Management to enable the operational planning, execution and data collection for all of Denali’s clinical trials.
Darren has nearly 25 years of clinical trial experience. Most recently he led the Development Operations group at Global Blood Therapeutics where his organization successfully planned and implemented the clinical trial strategy that led to the approval of a novel treatment for patients with sickle cell disease. Darren has led Development Operations, Clinical Operations and/or Outsourcing and Contracts groups at a number of organizations including Principia Biopharma, Exelixis, Elan Pharmaceuticals, Genentech and PPD.
Darren received his Bachelor of Science in Nursing from Southern Illinois University at Edwardsville and his Juris Doctorate from Washington University in St. Louis. Before starting his industry career, Darren worked as a Registered Nurse in an intensive care burn unit in St. Louis, Missouri and also practiced law in Wilmington, North Carolina.
Kimberly Scearce-Levie
Vice President, Translational Sciences
Kimberly Scearce-Levie
Vice President, Translational Sciences
Kimberly Scearce-Levie is Head of Translational Sciences at Denali Therapeutics. In this role, she leads efforts to develop translational biomarkers that deepen our understanding of neurodegenerative diseases and can be used to evaluate the biological response to potential therapeutics. Her team works closely with colleagues across Discovery, Development Sciences and Clinical Development to execute Denali’s biomarker-driven development strategy and enable rigorous clinical decision-making.
Kimberly is an experienced drug developer, having previously worked as Associate Director of Translational Neuroscience at Genentech. In that role, she built a translational group that developed, characterized and used animal models to test the effects of large and small molecule candidate therapeutics on biological pathways relevant to neurological disease.
Kimberly has over 70 peer reviewed publications exploring disease-related neuroscience and the relationship between specific signaling events and complex changes in brain health and behavior. Before joining industry, she led the behavioral core laboratory at the Gladstone Institute for Neurological Disease at UCSF while performing postdoctoral research with Dr. Lennart Mucke. She received her PhD in Neurobiology and Behavior from Columbia University and a Bachelor’s degree in Cognitive Science from Harvard University.
Laura Hansen
Vice President, Investor Relations
Laura Hansen
Vice President, Investor Relations
Laura leads Investor Relations at Denali, bringing more than two decades of experience in corporate and scientific communications for biotech companies.
Prior to Denali, she was Vice President of Corporate Affairs at BlackThorn Therapeutics, a privately held company focused on developing precision medicines for neuropsychiatric disorders. Before joining BlackThorn, she was Vice President of Investor Relations at Aimmune Therapeutics, Inc., a leading food allergy therapeutics company. Prior to that, she held positions in corporate communications at Threshold Pharmaceuticals, Inc., and FibroGen, Inc. At both companies, she was also responsible for scientific communications related to novel therapeutic platforms in oncology, fibrosis, and anemia.
Laura has a Ph.D. in Biological Sciences and a B.S. in Zoology from The University of Texas at Austin.
Leah Frautschy
Vice President, Clinical Manufacturing
Leah Frautschy
Vice President, Clinical Manufacturing
Leah Frautschy is the Vice President, Clinical Manufacturing for Denali. She is responsible for building and leading Denali’s clinical manufacturing capability.
Leah has over 25 years of experience in process development, manufacturing, facility engineering and senior leadership roles at Genentech. Her broad background includes initiatives in quality improvement and extensive health authority interactions. Her most recent role before joining Denali was the Senior Director of Engineering for the Clinical Supply Center facility currently under construction in South San Francisco.
Leah holds a Master of Engineering in Professional Practice degree from University of Wisconsin, Madison and a Bachelor of Chemical Engineering degree from the Univerity of Minnesota, Twin Cities.
Board of Directors
Douglas Cole
Managing Partner of Flagship Pioneering
Douglas Cole
Managing Partner of Flagship Pioneering
Doug Cole joined Flagship Pioneering in 2001 focusing on life sciences.
He holds an A.B. magna cum laude with high distinction in english from Dartmouth College, where he was a senior fellow and a member of Phi Beta Kappa, and an M.D. from the University of Pennsylvania School of Medicine, where he was a member of Alpha Omega Alpha. He obtained post-graduate training in medicine at the Johns Hopkins Hospital in Baltimore, MD and in neurology at the Massachusetts General Hospital in Boston, MA.
Before joining Flagship, Doug was instructor in neurology at Harvard Medical School and assistant in neurology at the Massachusetts General Hospital; medical director at Cytotherapeutics, in Providence, RI; and program executive at Vertex Pharmaceuticals, Inc., in Cambridge, MA.
At Flagship, Doug has co-founded Ensemble Therapeutics, Permeon Biologics, Moderna Therapeutics, Syros Pharmaceuticals, Sigilon Therapeutics, and Foghorn Therapeutics. He has led investments in Agios Pharmaceuticals, Alvine Pharmaceuticals, Avedro, CombinatoRx, Concert Pharmaceuticals, Denali Therapeutics, Editas, Quanterix Corporation, Receptos, Seventh Sense Biosystems, Tetraphase Pharmaceuticals, and Torque. He currently serves on the board of directors of Denali, Editas, Foghorn, Quanterix, Sigilon, Taris, and Torque. He formerly served on the board of directors of Avedro, AVEO Pharmaceuticals, CombinatoRx, Concert, CGI, KSQ, Moderna, Morphotek, Receptos, Resolvyx, Selecta, Seventh Sense and Tetraphase.
Doug is a member of the scientific advisory board and the board of directors of the Spinal Muscular Atrophy Foundation.
Jennifer Cook
Member of the Board of Directors
Jennifer Cook
Member of the Board of Directors
Jennifer Cook is Chief Executive Officer of GRAIL. Previously, Jennifer was at Roche Pharmaceuticals/Genentech where she held a number of senior management positions, covering the full lifecycle of product development and commercialization. From 2013 to 2016 she was Head of Region Europe for Roche Pharmaceuticals, where she was responsible for the commercial success of Europe and leading more than 5,500 employees across the 28 countries of the region. Other key positions during her 25-year tenure at Roche/Genentech included leading Global Clinical Operations, US and Global Product Portfolio Management, a US Commercial Business Unit, and Market Development.
Jennifer started her career in research and early development at Genentech and a venture-backed startup company. In 2016, Jennifer was recognized for her contributions to the healthcare industry and inspirational leadership when she was named Woman of the Year by the Healthcare Businesswomen’s Association. Jennifer holds a BA in human biology and an MS in biology from Stanford University, as well as an MBA from the Haas School of Business at University of California, Berkeley.
Jay Flatley
Chairman of Illumina, inc.
Jay Flatley
Chairman of Illumina, inc.
Jay led Illumina as CEO from 1999 until 2016, served as Executive Chairman from July 2016 to December 2019, and now serves as Chairman of the Board of Directors. During his tenure as CEO, he took the company from $1.3 million in sales in 2000 to $2.2 billion in 2015, representing a compound annual growth rate of 64 percent. He oversaw the company’s expansion from microarrays into next-generation sequencing with the acquisition of Solexa in 2006, and from research into clinical and applied markets. Under his leadership, Illumina was named multiple times to the Deloitte & Touche Fast 50 and Fast 500 lists, as well as to the Forbes 25 Fastest-Growing Tech Companies (2007, 2009 and 2010), the Fortune 100 Fastest-Growing Companies (2010 and 2011) lists, and recognition by MIT Technology Review as the World’s Smartest Company in 2014.
In addition to his work at Illumina, he serves on the Boards of Directors at Coherent, Denali, Iridia, on the Board of Trustees for The Salk Institute, and is an Advisory Board member for UC San Diego’s Moores Cancer Center.
Previously, Jay served on the Board of Juno Therapeutics until their acquisition by Celgene in 2018, and served as President and Chief Executive Officer of Molecular Dynamics, later acquired by Amersham Pharmacia Biotech and now a part of GE Healthcare. As a co-founder and member of the board of directors for Molecular Dynamics he led the company to its initial public offering in 1993. While there, he also helped Molecular Dynamics develop and launch over 15 major instrumentation systems, including the first capillary-based DNA sequencer. Prior to joining Molecular Dynamics, Jay was Vice President of Engineering and Strategic Planning for Plexus Computers, Executive Vice President for Manning Technologies and held various positions at Spectra Physics.
Jay received a B.A. in economics from Claremont McKenna College and a B.S. and M.S. (summa cum laude) in industrial engineering from Stanford University.
Peter Klein
Member of the Board of Directors
Peter Klein
Member of the Board of Directors
Peter Klein joined the Board of Directors as an independent director. Mr. Klein has 25 years of experience as a senior finance executive. He served as Chief Financial Officer of Microsoft Corporation from November 2009 until May 2013 and spent over 11 years at Microsoft. Most recently, he served as Chief Financial Officer of WME, a global leader in sports and entertainment marketing, from January 2014 until June 2014.
Peter holds a B.A. from Yale University and an M.B.A from University of Washington. He also serves on the board of directors of Apptio Inc. and F5 Networks, Inc., both publicly traded companies.
Robert Nelsen
Managing Director and Co-Founder of Arch Venture Partners
Robert Nelsen
Managing Director and Co-Founder of Arch Venture Partners
Robert Nelsen is a co-founder and a Managing Director of ARCH Venture Partners. He joined ARCH at its founding and played a significant role in the early sourcing, financing and development of more than 100 companies, including nineteen which have reached valuations exceeding $1 billion. His seed and early-stage investments include Illumina (ILMN); Alnylam Pharmaceuticals, Juno Therapeutics, Unity Biotechnology, Sienna Biopharmaceuticals, Vir Biotechnology, Agios Pharmaceuticals, Sage Therapeutics, GRAIL, Ikaria; Kythera Biopharmaceuticals, Receptos, Aviron, Denali Therapeutics, Rubius Therapeutics, KSQ Therapeutics, Beam Therapeutics, NetBot; bluebird bio, R2 Technology; XenoPort, Caliper Life Sciences, Trubion Pharmaceuticals, Adolor,; deCODE Genetics; Array BioPharma, Editas, IDUN Pharmaceuticals; Classmates.com; Hua Medicine; Fate Therapeutics, WuxiNextCODE; and Everyday Learning Corporation.
Mr. Nelsen is a director of Vir Bio, GRAIL, Sienna Biopharmaceuticals, Beam Therapeutics, Unity Biotechnology, Denali Therapeutics, Arivale, Syros Pharmaceuticals, and serves as Chairman of Hua Medicine, among others. He previously served as a Trustee of the Fred Hutchinson Cancer Research Institute, the Institute for Systems Biology, and was a director of the National Venture Capital Association. Mr. Nelsen holds an M.B.A. from the University of Chicago and a B.S. from the University of Puget Sound with majors in economics and biology.
Vicki Sato
Chairman of Denali Therapeutics
Vicki Sato
Chairman of Denali Therapeutics
Vicki L. Sato, Ph.D., serves as Chairman of the board of directors at Denali. Vicki served as the Professor of Management Practice at Harvard Business School, where she taught from 2006-2017. During this time, she also had an appointment as Professor of the Practice in the Department of Molecular and Cell Biology, Harvard University. In addition to her academic work, she is a business advisor to enterprises in the biotechnology and pharmaceutical industries. Before returning to academia, Vicki spent nearly 14 years at Vertex Pharmaceuticals, joining in 1992 as Chief Scientific Officer with responsibility for research and development. In 2000, she was named President of Vertex with general management responsibility for business and corporate development, commercial operations, legal, and finance, in addition to research and development. Before joining Vertex, Vicki was vice president of research at Biogen, Inc., where she led research programs in the areas of inflammation, thrombosis, and HIV disease, and was a member of the executive management team of the company. She also served as a member of the Biogen Scientific Board.
In addition to Vicki’s role at Denali, she is a member of the board of directors of publicly held companies Bristol Myers Squibb Company and Borg Warner Corporation. She is also Chair of the board of directors for Vir Biotechnology. Vicki continues to be a member of the board of Advisors of the Isabella Stewart Gardner Museum, having been Chair of the Advisors for a number of years. She received her A.B. from Radcliffe College, and her A.M. and Ph.D. degrees from Harvard University. Following postdoctoral work at both the University of California Berkeley and Stanford Medical Center, Vicki was appointed to the faculty of Harvard University, where she was an assistant and associate professor of biology.
David Schenkein
General Partner, GV
David Schenkein
General Partner, GV
Dr. Schenkein joined Agios in August 2009 as the Chief Executive Officer and a member of our board of directors and has been a hematologist and medical oncologist for more than 20 years. He currently serves as an adjunct attending physician in hematology at Tufts Medical Center. Prior to joining Agios, from March 2006 to July 2009, Dr. Schenkein was the Senior Vice President, clinical hematology/oncology, at Genentech, Inc., a pharmaceutical company, where he was responsible for numerous successful oncology drug approvals and leading the medical and scientific strategies for their BioOncology portfolio.
While at Genentech, he served as an adjunct clinical professor of medical oncology at Stanford University School of Medicine. Prior to joining Genentech, he served as the Senior Vice President of clinical research at Millennium Pharmaceuticals, Inc. (a wholly-owned subsidiary of Takeda Pharmaceuticals Company Limited), overseeing the clinical development and worldwide approval of Velcade®, a first-in-class cancer therapy now approved to treat multiple myeloma and Non-Hodgkin's lymphoma. He currently serves on the board of directors of Foundation Medicine, Inc., bluebird bio, Inc., and Denali Therapeutics Inc.
Dr. Schenkein holds a B.A. in chemistry from Wesleyan University and an M.D. from the State University of New York Upstate Medical School.
Marc Tessier-Lavigne
President, Stanford University
Marc Tessier-Lavigne
President, Stanford University
Dr. Tessier-Lavigne was born in Trenton, Ontario, Canada. He received undergraduate degrees in physics from McGill University and in philosophy and physiology from Oxford University, where he was a Rhodes Scholar. He earned a Ph.D. in physiology from University College London (UCL) and performed postdoctoral work at UCL and at Columbia University. He then held faculty positions at the University of California, San Francisco (UCSF) and subsequently at Stanford University, where he was the Susan B. Ford Professor in the School of Humanities and Sciences. While at UCSF and Stanford he was also an investigator with the Howard Hughes Medical Institute.
A world leader in the study of brain development and repair, Dr. Tessier-Lavigne’s research has focused on the cause and treatment of degenerative brain diseases such as Alzheimer’s and Parkinson’s, as well as on therapies for spinal cord injuries. Dr. Tessier-Lavigne and his colleagues revealed how neural circuits in the brain form during embryonic development by identifying molecules that direct the formation of connections among nerve cells. Defects in these mechanisms lead to neurological disorders. These mechanisms also provide targets to assist regeneration of nerve connections after trauma. His contributions have been recognized by numerous prizes and honors, including his election as a Member of the National Academy of Sciences (USA), the National Academy of Medicine (USA), and the American Philosophical Society and as a Fellow of the Royal Society (UK), the Royal Society of Canada, the Academy of Medical Sciences (UK), the American Association for the Advancement of Science, and the American Academy of Arts and Sciences.
In 2003, Dr. Tessier-Lavigne was recruited to biotechnology company Genentech, where he became Executive Vice President for Research and Chief Scientific Officer, directing 1,400 scientists in disease research and drug discovery for cancer, immune disorders, infectious diseases, and neurodegenerative diseases, while maintaining an active research laboratory.
In 2011, Dr. Tessier-Lavigne became President of The Rockefeller University, a leading biomedical research university in New York City. At Rockefeller, Dr. Tessier-Lavigne worked with faculty, students, staff and trustees to develop and execute a nine-year strategic plan focused on junior and mid-career faculty recruitment; enhancement of graduate and postdoctoral education; establishment of interdisciplinary research programs and acquisition of advanced research instruments; expansion of the university’s translational medical infrastructure; and a $500 million, two-acre campus expansion project in the heart of Manhattan that broke ground in 2015.
Early in his tenure as Stanford president, Dr. Tessier-Lavigne, in partnership with Stanford Provost Persis Drell, launched a long-range planning process that led to the announcement of a new strategic vision for Stanford’s future in spring 2018. Built on more than 2,800 ideas received from across the Stanford community, the vision sets priorities across four areas: values, research, education and community. Now in its design phase, the long-range vision promises to chart a purposeful course for the university in its continued efforts to spark knowledge and creativity, advance learning, and accelerate impact for the benefit of humanity.
At a national and international level, Dr. Tessier-Lavigne has been an active spokesperson for societal support of science, through editorials, advocacy and congressional testimony.
Dr. Tessier-Lavigne serves on several scientific advisory, non-profit, and corporate boards. He has co-founded two start-up companies, targeting neurological disease and neurodegenerative disease.
Nancy A. Thornberry
CEO, Kallyope
Nancy A. Thornberry
CEO, Kallyope
Nancy A. Thornberry is CEO at Kallyope, a biotechnology company headquartered in NYC focused on the gut-brain axis. She was formerly Senior Vice President and Franchise Head, Diabetes and Endocrinology, for Merck & Co. Inc. In this role, she led discovery and clinical research in diabetes, osteoporosis, fertility and contraception. Prior to her role as Franchise Head, Nancy initiated and led Merck’s dipeptidyl peptidase 4 (DPP-4) project, which resulted in the discovery of JANUVIA® for the treatment of Type 2 diabetes.
Nancy began her career with Merck Research Laboratories in 1979 as a biochemist and served in many roles of increasing responsibility, culminating in her role as Franchise Head. Beyond her contributions in the metabolic disease area, she has achieved several notable scientific accomplishments, including the identification of the first caspase, interleukin-1β converting enzyme (ICE/caspase-1). For her scientific contributions she has received numerous awards, including the Merck Presidential Fellowship, Merck Directors Award, Heroes of Chemistry Award by the American Chemical Society, and in 2011 received the Pharmaceuticals Research and Manufacturers of America (PhRMA) Discoverers Award, which honors research scientists whose work has been of special benefit to humankind.
In addition to her role at Kallyope, Nancy is currently on the Board of Directors of Schrodinger. She is also a member of NYC’s Mayor’s Life Sciences (LifeSciNYC) Advisory Council.
Ryan Watts
Chief Executive Officer
Ryan Watts
Chief Executive Officer
Ryan Watts is the Chief Executive Officer of Denali Therapeutics. He is a co-founder, President and a member of the Board of Directors.
Under Ryan's leadership, Denali has advanced multiple therapeutic candidates into clinical testing for Parkinson’s disease, Alzheimer’s disease, and ALS. Denali has invented a proprietary blood-brain barrier platform for delivery of therapeutic proteins to the brain. Ryan has also led efforts to raise significant capital to advance Denali’s therapeutic pipeline and has been instrumental in forging partnerships to accelerate the discovery and development of medicines for neurodegeneration.
Ryan previously served as Director of the Department of Neuroscience at Genentech. During his tenure there, he led the company’s re-entry into neuroscience. The Watts laboratory focused on drug discovery for cancer and Alzheimer’s disease, with an emphasis on understanding mechanisms of neurodegeneration guided by human genetics. His lab also studied various aspects of blood-brain barrier biology and delivery.
Ryan obtained his Ph.D. from Stanford University’s Department of Biological Sciences and his B.S. in Biology from the University of Utah.
Scientific Advisory Board
Denali's Scientific Advisory Board brings experience from both industry and academia to provide insight around biological pathways, therapeutic strategies, and biomarker development.
Scott Biller, PhD
Strategic Advisor, Agios
Scott Biller, PhD
Strategic Advisor, Agios
Scott Biller, PhD
Strategic Advisor, Agios
David M. Holtzman, MD
Professor and Chairman Dept. of Neurology, Washington University School of Medicine
David M. Holtzman, MD
Professor and Chairman Dept. of Neurology, Washington University School of Medicine
David M. Holtzman, MD
Professor and Chairman Dept. of Neurology, Washington University School of Medicine
Eric Reiman, MD
Executive Director, Banner Alzheimer's Institute
Eric Reiman, MD
Executive Director, Banner Alzheimer's Institute
Eric Reiman, MD
Executive Director, Banner Alzheimer's Institute
Kevan Shokat, PhD
University of California San Francisco
Kevan Shokat, PhD
University of California San Francisco
Kevan Shokat, PhD
University of California San Francisco
Melissa Starovasnik, PHD
Independent Board Member & Scientific Advisor
Melissa Starovasnik, PHD
Independent Board Member & Scientific Advisor
Melissa Starovasnik, PHD
Independent Board Member & Scientific Advisor
Marc Tessier-Lavigne, PhD
President, Stanford University
Marc Tessier-Lavigne, PhD
President, Stanford University
Marc Tessier-Lavigne, PhD
President, Stanford University
Stacie Weninger, PHD
President, FBRI
Stacie Weninger, PHD
President, FBRI
Stacie Weninger, PHD
President, FBRI
Tom Stocky
Member of the Scientific Advisory Board, Denali Therapeutics
Tom Stocky
Member of the Scientific Advisory Board, Denali Therapeutics
Tom Stocky
Member of the Scientific Advisory Board, Denali Therapeutics
Tom was most recently a technology fellow at Denali Therapeutics, where he explored how technology could support our discovery and development efforts. He helped expand the use of artificial intelligence and machine learning techniques to support our discovery work, and helped further develop our digital strategy for engaging with patients. He continues to advise on these areas in his role on the scientific advisory board.
Tom has built technology products for more than 15 years. As VP of Search at Facebook, he grew the service to more than 2 billion searches per day across the community's more than 3 trillion posts. He also led teams responsible for profile, entity graph, and language technology. At Google, he helped start the developer products team and was part of the founding team for Google App Engine, which laid the foundation for Google's Cloud Platform. He later led teams working on Google search, commerce, and travel products. As Head of Learning Platform at the Chan Zuckerberg Initiative, he oversaw the engineering, product, and design teams for their education technology efforts.
In addition to his role at Denali, Tom serves on the board of directors of the Banner Alzheimer's Foundation. Tom holds an MEng and BS in Computer Science & Electrical Engineering from MIT and an MBA from MIT Sloan.